The country was the first Western Balkan nation to sign a Stabilisation and Association Agreement (SAA) with the EU, which entered into force in April 2004.

The former Yugoslav Republic of Macedonia was granted candidate country status for EU membership in December 2005. In February 2008, the EU adopted the Accession Partnership for the country, which updated the previous European Partnership agreement of January 2006. Citizens of the former Yugoslav Republic of Macedonia were granted visa-free travel to the Schengen area in December 2009.

In June 2018, Macedonia and Greece resolved the conflict with an agreement that the country should rename itself Republic of North Macedonia. This renaming came into effect in February 2019.

Official visit by David SASSOLI, EP President to Skopje, North Macedonia - Press conference with Zoran ZAEV, Prime Minister of of North Macedonia